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| カタログ番号 | HP187015 |
|---|---|
| 説明 |
Anti-Human NEU3/Sialidase-3 Antibody (1A038) [1A038] (HP187015) is a mouse monoclonal antibody detecting NEU3 in ELISA, WB. Suitable for Human.
|
| 種反応性 | Human |
| アプリケーション | ELISA, WB |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG2b |
| クローンID | 1A038 |
| 免疫原 | Synthesized peptide. |
| ターゲット | Isoform 2 of Sialidase-3, 3.2.1.18, Ganglioside sialidasedis, Membrane sialidase, N-acetyl-alpha-neuraminidase 3, NEU3 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q9UQ49 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Sialidase-3 (NEU3) is a ~48 kDa protein. Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR. Desialylates EGFR and activates downstream signaling in proliferating cells. Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes. 1. Wada, T. et al. (1999) Biochemical and biophysical research communications 261, 21-7. PMID: 10405317 2. Monti, E. et al. (2000) The Biochemical journal 349, 343-51. PMID: 10861246 3. Wang, Y. et al. (2001) European journal of biochemistry 268, 2201-8. PMID: 11298736 4. Wang, Y. et al. (2002) The Journal of biological chemistry 277, 26252-9. PMID: 12011038 5. Yamaguchi, K. et al. (2005) The Biochemical journal 390, 85-93. PMID: 15847605 6. Albohy, A. et al. (2010) Glycobiology 20, 1127-38. PMID: 20511247 7. Rodriguez-Walker, M. et al. (2017) Scientific reports 7, 4167. PMID: 28646141 8. Wada, T. et al. (2007) Oncogene 26, 2483-90. PMID: 17334392 9. Mozzi, A. et al. (2015) Glycobiology 25, 855-68. PMID: 25922362 |
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human NEU3/Sialidase-3 Antibody (1A038)
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