Anti-Human NEU3/Sialidase-3 Polyclonal Antibody (HP187014)

Name: Anti-Human NEU3/Sialidase-3 Polyclonal Antibody
Brand: abinScience
SKU: HP187014
Price: 96 USD
Availability: InStock

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Número de catálogo

HP187014

Descripción

Anti-Human NEU3/Sialidase-3 Polyclonal Antibody (HP187014) is a rabbit polyclonal antibody detecting Sialidase-3 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human NEU3/Sialidase-3 (Met1-Asn428).

Objetivo

N-acetyl-alpha-neuraminidase 3, NEU3, Sialidase-3, Ganglioside sialidasedis, Membrane sialidase

Purificación

Purified by antigen affinity column.

Número de acceso

Q9UQ49

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Sialidase-3 (NEU3) is a ~48 kDa protein. Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR. Desialylates EGFR and activates downstream signaling in proliferating cells. Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes.

1. Wada, T. et al. (1999) Biochemical and biophysical research communications 261, 21-7. PMID: 10405317

2. Monti, E. et al. (2000) The Biochemical journal 349, 343-51. PMID: 10861246

3. Wang, Y. et al. (2001) European journal of biochemistry 268, 2201-8. PMID: 11298736

4. Wang, Y. et al. (2002) The Journal of biological chemistry 277, 26252-9. PMID: 12011038

5. Yamaguchi, K. et al. (2005) The Biochemical journal 390, 85-93. PMID: 15847605

6. Albohy, A. et al. (2010) Glycobiology 20, 1127-38. PMID: 20511247

7. Rodriguez-Walker, M. et al. (2017) Scientific reports 7, 4167. PMID: 28646141

8. Wada, T. et al. (2007) Oncogene 26, 2483-90. PMID: 17334392

9. Mozzi, A. et al. (2015) Glycobiology 25, 855-68. PMID: 25922362

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human NEU3/Sialidase-3 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human NEU3/Sialidase-3 Polyclonal Antibody (HP187014)

Vista general

Imágenes

Referencias

Datasheet

SDS