Anti-Human NEU3/Sialidase-3 Monoclonal Antibody (1A038) (HP187015)

Name: Anti-Human NEU3/Sialidase-3 Monoclonal Antibody (1A038)
Brand: abinScience
SKU: HP187015
Price: 106 USD
Availability: InStock

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Overview

Catalog No.	HP187015
Description	Anti-Human NEU3/Sialidase-3 Antibody (1A038) [1A038] (HP187015) is a mouse monoclonal antibody detecting NEU3 in ELISA, WB. Suitable for Human.
Species reactivity	Human
Applications	ELISA, WB
Host species	Mouse
Clonality	Monoclonal
Isotype	IgG2b
Clone ID	1A038
Immunogen	Synthesized peptide.
Target	Isoform 2 of Sialidase-3, 3.2.1.18, Ganglioside sialidasedis, Membrane sialidase, N-acetyl-alpha-neuraminidase 3, NEU3
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9UQ49
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Sialidase-3 (NEU3) is a ~48 kDa protein. Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR. Desialylates EGFR and activates downstream signaling in proliferating cells. Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes. 1. Wada, T. et al. (1999) Biochemical and biophysical research communications 261, 21-7. PMID: 10405317 2. Monti, E. et al. (2000) The Biochemical journal 349, 343-51. PMID: 10861246 3. Wang, Y. et al. (2001) European journal of biochemistry 268, 2201-8. PMID: 11298736 4. Wang, Y. et al. (2002) The Journal of biological chemistry 277, 26252-9. PMID: 12011038 5. Yamaguchi, K. et al. (2005) The Biochemical journal 390, 85-93. PMID: 15847605 6. Albohy, A. et al. (2010) Glycobiology 20, 1127-38. PMID: 20511247 7. Rodriguez-Walker, M. et al. (2017) Scientific reports 7, 4167. PMID: 28646141 8. Wada, T. et al. (2007) Oncogene 26, 2483-90. PMID: 17334392 9. Mozzi, A. et al. (2015) Glycobiology 25, 855-68. PMID: 25922362
Note	For research use only.

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SDS-PAGE for Anti-Human NEU3/Sialidase-3 Antibody (1A038)

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Datasheet

Anti-Human NEU3/Sialidase-3 Monoclonal Antibody (1A038).pdf

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Anti-Human NEU3/Sialidase-3 Monoclonal Antibody (1A038) (HP187015)

Overview

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References

Datasheet

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