Anti-Human NEU3/Sialidase-3 Polyclonal Antibody (HP187014)

Name: Anti-Human NEU3/Sialidase-3 Polyclonal Antibody
Brand: abinScience
SKU: HP187014
Price: 96 USD
Availability: InStock

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Каталожный номер

HP187014

Описание

Anti-Human NEU3/Sialidase-3 Polyclonal Antibody (HP187014) is a rabbit polyclonal antibody detecting Sialidase-3 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human NEU3/Sialidase-3 (Met1-Asn428).

Цель

N-acetyl-alpha-neuraminidase 3, NEU3, Sialidase-3, Ganglioside sialidasedis, Membrane sialidase

Очистка

Purified by antigen affinity column.

Номер доступа

Q9UQ49

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Sialidase-3 (NEU3) is a ~48 kDa protein. Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR. Desialylates EGFR and activates downstream signaling in proliferating cells. Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes.

1. Wada, T. et al. (1999) Biochemical and biophysical research communications 261, 21-7. PMID: 10405317

2. Monti, E. et al. (2000) The Biochemical journal 349, 343-51. PMID: 10861246

3. Wang, Y. et al. (2001) European journal of biochemistry 268, 2201-8. PMID: 11298736

4. Wang, Y. et al. (2002) The Journal of biological chemistry 277, 26252-9. PMID: 12011038

5. Yamaguchi, K. et al. (2005) The Biochemical journal 390, 85-93. PMID: 15847605

6. Albohy, A. et al. (2010) Glycobiology 20, 1127-38. PMID: 20511247

7. Rodriguez-Walker, M. et al. (2017) Scientific reports 7, 4167. PMID: 28646141

8. Wada, T. et al. (2007) Oncogene 26, 2483-90. PMID: 17334392

9. Mozzi, A. et al. (2015) Glycobiology 25, 855-68. PMID: 25922362

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human NEU3/Sialidase-3 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-Human NEU3/Sialidase-3 Polyclonal Antibody (HP187014)

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