

| Каталожный номер | HP387014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human NLRX1 Polyclonal Antibody (HP387014) is a rabbit polyclonal antibody detecting NLRX1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human NLRX1 (Arg667-Ser975). | ||||||||
| Цель | NLR family member X1, NOD5, Caterpiller protein 11.3, NOD9, Nucleotide-binding oligomerization domain protein 9, NLRX1, Nucleotide-binding oligomerization domain protein 26, Nucleotide-binding oligomerization domain protein 5, NOD26, CLR11.3 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q86UT6 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | NLR family member X1 (NLRX1) is a ~107 kDa protein. Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species. 1. Moore, CB. et al. (2008) Nature 451, 573-7. PMID: 18200010 2. Lei, Y. et al. (2012) Immunity 36, 933-46. PMID: 22749352 3. Li, H. et al. (2016) Molecular immunology 76, 90-7. PMID: 27393910 4. Tattoli, I. et al. (2008) EMBO reports 9, 293-300. PMID: 18219313 | ||||||||
| Примечание | For research use only. |
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