Anti-Human NPPB Recombinant Antibody (SAA0281) (HB840013)

Name: Anti-Human NPPB Recombinant Antibody (SAA0281)
Brand: abinScience
SKU: HB840013
Price: 196 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HB840013

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG1

ID de clon

SAA0281

Objetivo

NT-proBNP(1-76), preproBNP, BNP(1-32), BNP(4-32), proBNP, Brain natriuretic peptide, BNP, des-SerPro-BNP, NPPB, NT-pro-BNP, proBNP(79-108), Iso-ANP, Natriuretic peptides B, Gamma-brain natriuretic peptide, Brain natriuretic factor prohormone, BNP-32

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

P16860

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

Natriuretic peptides B (NPPB/BNP) is a ~14 kDa protein. Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3.

1. Koller, KJ. et al. (1991) Science (New York, N.Y.) 252, 120-3. PMID: 1672777

2. Heublein, DM. et al. (2007) Hypertension (Dallas, Tex. : 1979) 49, 1114-9. PMID: 17372040

3. Yoshimura, M. et al. (1991) Circulation 84, 1581-8. PMID: 1914098

4. Jensen, KT. et al. (1998) The American journal of physiology 274, F63-72. PMID: 9458824

5. Liang, F. et al. (2007) Journal of the American College of Cardiology 49, 1071-8. PMID: 17349887

6. Ralat, LA. et al. (2011) The Journal of biological chemistry 286, 4670-9. PMID: 21098034

7. Huntley, BK. et al. (2015) Circulation. Heart failure 8, 89-97. PMID: 25339504

Referencias

1. Li J, et al. Enhancement of an outwardly rectifying chloride channel in hippocampal pyramidal neurons after cerebral ischemia. Brain Res. 2016 Aug 1;1644:107-17. [HB840013]
2. Park M, et al. Double Blockade of Glioma Cell Proliferation and Migration by Temozolomide Conjugated withNPPB, a Chloride Channel Blocker. ACS Chem Neurosci. 2016 Mar 16;7(3):275-85. [HB840013]

Nota

For research use only.

Imágenes