Anti-NPPB Polyclonal Antibody (HB840014)

Name: Anti-NPPB Polyclonal Antibody
Brand: abinScience
SKU: HB840014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HB840014

Description

Anti-NPPB Polyclonal Antibody (HB840014) is a rabbit polyclonal antibody detecting NPPB in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human NPPB (His27-Arg102).

Target

NT-proBNP(1-76), preproBNP, BNP(1-32), BNP(4-32), proBNP, Brain natriuretic peptide, BNP, des-SerPro-BNP, NPPB, NT-pro-BNP, proBNP(79-108), Iso-ANP, Natriuretic peptides B, Gamma-brain natriuretic peptide, Brain natriuretic factor prohormone, BNP-32

Purification

Purified by antigen affinity column.

Accession

P16860

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Natriuretic peptides B (NPPB/BNP) is a ~14 kDa protein. Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3.

1. Koller, KJ. et al. (1991) Science (New York, N.Y.) 252, 120-3. PMID: 1672777

2. Heublein, DM. et al. (2007) Hypertension (Dallas, Tex. : 1979) 49, 1114-9. PMID: 17372040

3. Yoshimura, M. et al. (1991) Circulation 84, 1581-8. PMID: 1914098

4. Jensen, KT. et al. (1998) The American journal of physiology 274, F63-72. PMID: 9458824

5. Liang, F. et al. (2007) Journal of the American College of Cardiology 49, 1071-8. PMID: 17349887

6. Ralat, LA. et al. (2011) The Journal of biological chemistry 286, 4670-9. PMID: 21098034

7. Huntley, BK. et al. (2015) Circulation. Heart failure 8, 89-97. PMID: 25339504

Note

For research use only.

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