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| カタログ番号 | HB840013 | ||||||
|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||
| アプリケーション | ELISA, IHC, WB | ||||||
| 宿主種 | Mouse | ||||||
| クローン性 | Monoclonal | ||||||
| アイソタイプ | IgG1 | ||||||
| クローンID | SAA0281 | ||||||
| ターゲット | NT-proBNP(1-76), preproBNP, BNP(1-32), BNP(4-32), proBNP, Brain natriuretic peptide, BNP, des-SerPro-BNP, NPPB, NT-pro-BNP, proBNP(79-108), Iso-ANP, Natriuretic peptides B, Gamma-brain natriuretic peptide, Brain natriuretic factor prohormone, BNP-32 | ||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||||
| アクセッション番号 | P16860 | ||||||
| 形態 | Liquid | ||||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||||
| 背景 | Natriuretic peptides B (NPPB/BNP) is a ~14 kDa protein. Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3. 1. Koller, KJ. et al. (1991) Science (New York, N.Y.) 252, 120-3. PMID: 1672777 2. Heublein, DM. et al. (2007) Hypertension (Dallas, Tex. : 1979) 49, 1114-9. PMID: 17372040 3. Yoshimura, M. et al. (1991) Circulation 84, 1581-8. PMID: 1914098 4. Jensen, KT. et al. (1998) The American journal of physiology 274, F63-72. PMID: 9458824 5. Liang, F. et al. (2007) Journal of the American College of Cardiology 49, 1071-8. PMID: 17349887 6. Ralat, LA. et al. (2011) The Journal of biological chemistry 286, 4670-9. PMID: 21098034 7. Huntley, BK. et al. (2015) Circulation. Heart failure 8, 89-97. PMID: 25339504 | ||||||
| 参考文献 | 1. Li J, et al. Enhancement of an outwardly rectifying chloride channel in hippocampal pyramidal neurons after cerebral ischemia. Brain Res. 2016 Aug 1;1644:107-17. [HB840013] 2. Park M, et al. Double Blockade of Glioma Cell Proliferation and Migration by Temozolomide Conjugated withNPPB, a Chloride Channel Blocker. ACS Chem Neurosci. 2016 Mar 16;7(3):275-85. [HB840013] |
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| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human NPPB Antibody (SAA0281).
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