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| カタログ番号 | HP062014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human NXF1 Polyclonal Antibody (HP062014) is a rabbit polyclonal antibody detecting NXF1 in ELISA, IHC, WB. Suitable for Human, Rat.
Highlights
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| 種反応性 | Human, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NXF1 (Lys205-Lys347). | ||||||||
| ターゲット | mRNA export factor TAP, Nuclear RNA export factor 1, Tip-associating protein, TAP, Tip-associated protein, NXF1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9UBU9 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Nuclear RNA export factor 1 (NXF1) is a ~70 kDa protein. Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. 1. Tang, H. et al. (2000) The Journal of biological chemistry 275, 32694-700. PMID: 10924507 2. Hautbergue, GM. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 5154-9. PMID: 18364396 3. Katahira, J. et al. (2009) The EMBO journal 28, 556-67. PMID: 19165146 4. Grüter, P. et al. (1998) Molecular cell 1, 649-59. PMID: 9660949 5. Roundtree, IA. et al. (2017) eLife 6. PMID: 28984244 | ||||||||
| 注意事項 | For research use only. |
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