

| Каталожный номер | HP062014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human NXF1 Polyclonal Antibody (HP062014) is a rabbit polyclonal antibody detecting NXF1 in ELISA, IHC, WB. Suitable for Human, Rat.
Highlights
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| Реактивность видов | Human, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human NXF1 (Lys205-Lys347). | ||||||||
| Цель | mRNA export factor TAP, Nuclear RNA export factor 1, Tip-associating protein, TAP, Tip-associated protein, NXF1 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q9UBU9 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Nuclear RNA export factor 1 (NXF1) is a ~70 kDa protein. Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. 1. Tang, H. et al. (2000) The Journal of biological chemistry 275, 32694-700. PMID: 10924507 2. Hautbergue, GM. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 5154-9. PMID: 18364396 3. Katahira, J. et al. (2009) The EMBO journal 28, 556-67. PMID: 19165146 4. Grüter, P. et al. (1998) Molecular cell 1, 649-59. PMID: 9660949 5. Roundtree, IA. et al. (2017) eLife 6. PMID: 28984244 | ||||||||
| Примечание | For research use only. |
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