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| カタログ番号 | HC357014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human OS9 Polyclonal Antibody (HC357014) is a rabbit polyclonal antibody detecting OS9 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human OS9 (Asn32-Gln251). | ||||||||
| ターゲット | Protein OS-9, OS9, Amplified in osteosarcoma 9 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13438 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Protein OS-9 (OS9) is a ~75 kDa protein. Lectin component of the HRD1 complex, which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). Specifically recognizes and binds improperly folded glycoproteins as well as hyperglycosylated proteins, retain them in the ER, and transfers them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 as well as hyperglycosylated HSP90B1. 1. Christianson, JC. et al. (2008) Nature cell biology 10, 272-82. PMID: 18264092 2. Bernasconi, R. et al. (2008) The Journal of biological chemistry 283, 16446-54. PMID: 18417469 3. Alcock, F. et al. (2009) Journal of molecular biology 385, 1032-42. PMID: 19084021 4. Hosokawa, N. et al. (2009) The Journal of biological chemistry 284, 17061-17068. PMID: 19346256 5. Satoh, T. et al. (2010) Molecular cell 40, 905-16. PMID: 21172656 6. Dersh, D. et al. (2014) Molecular biology of the cell 25, 2220-34. PMID: 24899641 | ||||||||
| 注意事項 | For research use only. |
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