

| Каталожный номер | HC357014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human OS9 Polyclonal Antibody (HC357014) is a rabbit polyclonal antibody detecting OS9 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human OS9 (Asn32-Gln251). | ||||||||
| Цель | Protein OS-9, OS9, Amplified in osteosarcoma 9 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q13438 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Protein OS-9 (OS9) is a ~75 kDa protein. Lectin component of the HRD1 complex, which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). Specifically recognizes and binds improperly folded glycoproteins as well as hyperglycosylated proteins, retain them in the ER, and transfers them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 as well as hyperglycosylated HSP90B1. 1. Christianson, JC. et al. (2008) Nature cell biology 10, 272-82. PMID: 18264092 2. Bernasconi, R. et al. (2008) The Journal of biological chemistry 283, 16446-54. PMID: 18417469 3. Alcock, F. et al. (2009) Journal of molecular biology 385, 1032-42. PMID: 19084021 4. Hosokawa, N. et al. (2009) The Journal of biological chemistry 284, 17061-17068. PMID: 19346256 5. Satoh, T. et al. (2010) Molecular cell 40, 905-16. PMID: 21172656 6. Dersh, D. et al. (2014) Molecular biology of the cell 25, 2220-34. PMID: 24899641 | ||||||||
| Примечание | For research use only. |
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