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Anti-Human OTUD7B Polyclonal Antibody (HC193014)

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Vista general
Número de catálogoHC193014
Descripción
Anti-Human OTUD7B Polyclonal Antibody (HC193014) is a rabbit polyclonal antibody detecting OTUD7B. Suitable for Human and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human OTUD7B (Gln136-Ser438).
Objetivo Cellular zinc finger anti-NF-kappa-B protein, Cezanne, EC:3.4.19.12, OTU domain-containing protein 7B, OTUD7B, ZA20D1, Zinc finger A20 domain-containing protein 1, Zinc finger protein Cezanne
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso Q6GQQ9
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

OTU domain-containing protein 7B (OTUD7B) is a ~92 kDa protein. Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B. Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2.

1. Enesa, K. et al. (2008) The Journal of biological chemistry 283, 7036-45. PMID: 18178551
2. Hu, H. et al. (2016) The Journal of experimental medicine 213, 399-414. PMID: 26903241
3. Pareja, F. et al. (2012) Oncogene 31, 4599-608. PMID: 22179831
4. Evans, PC. et al. (2001) The Biochemical journal 357, 617-23. PMID: 11463333
5. Bremm, A. et al. (2010) Nature structural & molecular biology 17, 939-47. PMID: 20622874
6. Mevissen, TE. et al. (2013) Cell 154, 169-84. PMID: 23827681
7. Mevissen, TET. et al. (2016) Nature 538, 402-405. PMID: 27732584
8. Evans, PC. et al. (2003) The Journal of biological chemistry 278, 23180-6. PMID: 12682062
9. Wang, B. et al. (2017) Nature 545, 365-369. PMID: 28489822
Nota For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Volume
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g/mol
Formula
C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human OTUD7B Polyclonal Antibody

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