Human OTUD7B Recombinant Protein (N-His) (HC193012)

Name: Human OTUD7B Recombinant Protein (N-His)
Brand: abinScience
SKU: HC193012
Price: 211 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD):

Spec:

50ug
100ug
1mg

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.	HC193012
Description	Recombinant Human OTUD7B Protein, N-His (HC193012) expressed in E. coli, spanning Gln136-Ser438. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q6GQQ9
Protein length	Gln136-Ser438
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	36.73 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Cellular zinc finger anti-NF-kappa-B protein, Cezanne, EC:3.4.19.12, OTU domain-containing protein 7B, OTUD7B, ZA20D1, Zinc finger A20 domain-containing protein 1, Zinc finger protein Cezanne
Background	OTU domain-containing protein 7B is a ~92 kDa protein. Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B. Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2. 1. Enesa, K. et al. (2008) The Journal of biological chemistry 283, 7036-45. PMID: 18178551 2. Hu, H. et al. (2016) The Journal of experimental medicine 213, 399-414. PMID: 26903241 3. Pareja, F. et al. (2012) Oncogene 31, 4599-608. PMID: 22179831 4. Evans, PC. et al. (2001) The Biochemical journal 357, 617-23. PMID: 11463333 5. Bremm, A. et al. (2010) Nature structural & molecular biology 17, 939-47. PMID: 20622874 6. Mevissen, TE. et al. (2013) Cell 154, 169-84. PMID: 23827681 7. Mevissen, TET. et al. (2016) Nature 538, 402-405. PMID: 27732584 8. Evans, PC. et al. (2003) The Journal of biological chemistry 278, 23180-6. PMID: 12682062 9. Wang, B. et al. (2017) Nature 545, 365-369. PMID: 28489822
Note	For research use only

Images

References

Datasheet

Human OTUD7B Recombinant Protein (N-His).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Human OTUD7B Recombinant Protein (N-His) (HC193012)

Overview

Images

References

Datasheet

SDS

Quick access

Contact Us