Anti-Human OTUD7B Polyclonal Antibody (HC193014)

Name: Anti-Human OTUD7B Polyclonal Antibody
Brand: abinScience
SKU: HC193014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HC193014

Description

Anti-Human OTUD7B Polyclonal Antibody (HC193014) is a rabbit polyclonal antibody detecting OTUD7B. Suitable for Human and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human OTUD7B (Gln136-Ser438).

Target

Cellular zinc finger anti-NF-kappa-B protein, Cezanne, EC:3.4.19.12, OTU domain-containing protein 7B, OTUD7B, ZA20D1, Zinc finger A20 domain-containing protein 1, Zinc finger protein Cezanne

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q6GQQ9

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

OTU domain-containing protein 7B (OTUD7B) is a ~92 kDa protein. Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B. Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2.

1. Enesa, K. et al. (2008) The Journal of biological chemistry 283, 7036-45. PMID: 18178551

2. Hu, H. et al. (2016) The Journal of experimental medicine 213, 399-414. PMID: 26903241

3. Pareja, F. et al. (2012) Oncogene 31, 4599-608. PMID: 22179831

4. Evans, PC. et al. (2001) The Biochemical journal 357, 617-23. PMID: 11463333

5. Bremm, A. et al. (2010) Nature structural & molecular biology 17, 939-47. PMID: 20622874

6. Mevissen, TE. et al. (2013) Cell 154, 169-84. PMID: 23827681

7. Mevissen, TET. et al. (2016) Nature 538, 402-405. PMID: 27732584

8. Evans, PC. et al. (2003) The Journal of biological chemistry 278, 23180-6. PMID: 12682062

9. Wang, B. et al. (2017) Nature 545, 365-369. PMID: 28489822

Note

For research use only

Images

References

Datasheet

Anti-Human OTUD7B Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human OTUD7B Polyclonal Antibody (HC193014)

Overview

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References

Datasheet

SDS

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