中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HC193014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human OTUD7B Polyclonal Antibody (HC193014) is a rabbit polyclonal antibody detecting OTUD7B. Suitable for Human and Mouse.
Highlights
|
||||||||
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human OTUD7B (Gln136-Ser438). | ||||||||
| ターゲット | Cellular zinc finger anti-NF-kappa-B protein, Cezanne, EC:3.4.19.12, OTU domain-containing protein 7B, OTUD7B, ZA20D1, Zinc finger A20 domain-containing protein 1, Zinc finger protein Cezanne | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q6GQQ9 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 背景 | OTU domain-containing protein 7B (OTUD7B) is a ~92 kDa protein. Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B. Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2. 1. Enesa, K. et al. (2008) The Journal of biological chemistry 283, 7036-45. PMID: 18178551 2. Hu, H. et al. (2016) The Journal of experimental medicine 213, 399-414. PMID: 26903241 3. Pareja, F. et al. (2012) Oncogene 31, 4599-608. PMID: 22179831 4. Evans, PC. et al. (2001) The Biochemical journal 357, 617-23. PMID: 11463333 5. Bremm, A. et al. (2010) Nature structural & molecular biology 17, 939-47. PMID: 20622874 6. Mevissen, TE. et al. (2013) Cell 154, 169-84. PMID: 23827681 7. Mevissen, TET. et al. (2016) Nature 538, 402-405. PMID: 27732584 8. Evans, PC. et al. (2003) The Journal of biological chemistry 278, 23180-6. PMID: 12682062 9. Wang, B. et al. (2017) Nature 545, 365-369. PMID: 28489822 | ||||||||
| 注意事項 | For research use only |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
