

| Каталожный номер | HC193014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human OTUD7B Polyclonal Antibody (HC193014) is a rabbit polyclonal antibody detecting OTUD7B. Suitable for Human and Mouse.
Highlights
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| Реактивность видов | Human, Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human OTUD7B (Gln136-Ser438). | ||||||||
| Цель | Cellular zinc finger anti-NF-kappa-B protein, Cezanne, EC:3.4.19.12, OTU domain-containing protein 7B, OTUD7B, ZA20D1, Zinc finger A20 domain-containing protein 1, Zinc finger protein Cezanne | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q6GQQ9 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Фон | OTU domain-containing protein 7B (OTUD7B) is a ~92 kDa protein. Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B. Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2. 1. Enesa, K. et al. (2008) The Journal of biological chemistry 283, 7036-45. PMID: 18178551 2. Hu, H. et al. (2016) The Journal of experimental medicine 213, 399-414. PMID: 26903241 3. Pareja, F. et al. (2012) Oncogene 31, 4599-608. PMID: 22179831 4. Evans, PC. et al. (2001) The Biochemical journal 357, 617-23. PMID: 11463333 5. Bremm, A. et al. (2010) Nature structural & molecular biology 17, 939-47. PMID: 20622874 6. Mevissen, TE. et al. (2013) Cell 154, 169-84. PMID: 23827681 7. Mevissen, TET. et al. (2016) Nature 538, 402-405. PMID: 27732584 8. Evans, PC. et al. (2003) The Journal of biological chemistry 278, 23180-6. PMID: 12682062 9. Wang, B. et al. (2017) Nature 545, 365-369. PMID: 28489822 | ||||||||
| Примечание | For research use only |
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