Anti-Human PABPC1 Polyclonal Antibody (HY439014)

Name: Anti-Human PABPC1 Polyclonal Antibody
Brand: abinScience
SKU: HY439014
Price: 168 USD
Availability: InStock

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Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HY439014

Descripción

Anti-Human PABPC1 Polyclonal Antibody (HY439014) is a rabbit polyclonal antibody detecting PABPC1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human PABPC1 (Met10-Arg390).

Objetivo

PABP-1, PAB1, PABPC2, PABPC1, Polyadenylate-binding protein 1, Poly(A)-binding protein 1, PABP1

Purificación

Purified by antigen affinity column.

Número de acceso

P11940

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Polyadenylate-binding protein 1 (PABPC1) is a ~70 kDa protein. Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Involved in translationally coupled mRNA turnover.

1. Grosset, C. et al. (2000) Cell 103, 29-40. PMID: 11051545

2. Patel, GP. et al. (2006) The FEBS journal 273, 5678-90. PMID: 17212783

3. Lim, J. et al. (2014) Cell 159, 1365-76. PMID: 25480299

4. Schäffler, K. et al. (2010) RNA (New York, N.Y.) 16, 1488-99. PMID: 20573744

5. Zhu, S. et al. (2020) Nature communications 11, 1685. PMID: 32245947

6. Singh, G. et al. (2008) PLoS biology 6, e111. PMID: 18447585

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human PABPC1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo