Anti-Human PABPC1 Reference Antibody (Alextatug, RUO) (HY439016)

Name: Anti-Human PABPC1 Reference Antibody (Alextatug, RUO)
Brand: abinScience
SKU: HY439016
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HY439016
Description	Alextatug (HY439016) is a research-grade recombinant antibody targeting PABP-1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Clonality	Monoclonal
Isotype	IgG1-lambda
Expression system	Mammalian cells
Target	PABP-1, PAB1, PABPC2, PABPC1, Polyadenylate-binding protein 1, Poly(A)-binding protein 1, PABP1
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P11940
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2768264-93-1
Background	Polyadenylate-binding protein 1 (PABPC1) is a ~70 kDa protein. Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Involved in translationally coupled mRNA turnover. 1. Grosset, C. et al. (2000) Cell 103, 29-40. PMID: 11051545 2. Patel, GP. et al. (2006) The FEBS journal 273, 5678-90. PMID: 17212783 3. Lim, J. et al. (2014) Cell 159, 1365-76. PMID: 25480299 4. Schäffler, K. et al. (2010) RNA (New York, N.Y.) 16, 1488-99. PMID: 20573744 5. Zhu, S. et al. (2020) Nature communications 11, 1685. PMID: 32245947 6. Singh, G. et al. (2008) PLoS biology 6, e111. PMID: 18447585
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1, lambda Isotype Control antibody (HyHEL-10) (HP248107)

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SDS-PAGE for Research Grade Alextatug.

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Datasheet

Anti-Human PABPC1 Reference Antibody (Alextatug, RUO).pdf

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Anti-Human PABPC1 Reference Antibody (Alextatug, RUO) (HY439016)

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