Anti-Human PABPC1 Polyclonal Antibody (HY439014)

Name: Anti-Human PABPC1 Polyclonal Antibody
Brand: abinScience
SKU: HY439014
Price: 168 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

HY439014

Description

Anti-Human PABPC1 Polyclonal Antibody (HY439014) is a rabbit polyclonal antibody detecting PABPC1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PABPC1 (Met10-Arg390).

Target

PABP-1, PAB1, PABPC2, PABPC1, Polyadenylate-binding protein 1, Poly(A)-binding protein 1, PABP1

Purification

Purified by antigen affinity column.

Accession

P11940

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Polyadenylate-binding protein 1 (PABPC1) is a ~70 kDa protein. Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Involved in translationally coupled mRNA turnover.

1. Grosset, C. et al. (2000) Cell 103, 29-40. PMID: 11051545

2. Patel, GP. et al. (2006) The FEBS journal 273, 5678-90. PMID: 17212783

3. Lim, J. et al. (2014) Cell 159, 1365-76. PMID: 25480299

4. Schäffler, K. et al. (2010) RNA (New York, N.Y.) 16, 1488-99. PMID: 20573744

5. Zhu, S. et al. (2020) Nature communications 11, 1685. PMID: 32245947

6. Singh, G. et al. (2008) PLoS biology 6, e111. PMID: 18447585

Note

For research use only.

Images

References

Datasheet

Anti-Human PABPC1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human PABPC1 Polyclonal Antibody (HY439014)

Overview

Images

References

Datasheet

SDS

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