Anti-Human PABPC1 Polyclonal Antibody (HY439014)

Name: Anti-Human PABPC1 Polyclonal Antibody
Brand: abinScience
SKU: HY439014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HY439014

Description

Anti-Human PABPC1 Polyclonal Antibody (HY439014) is a rabbit polyclonal antibody detecting PABPC1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human PABPC1 (Met10-Arg390).

Cible

PABP-1, PAB1, PABPC2, PABPC1, Polyadenylate-binding protein 1, Poly(A)-binding protein 1, PABP1

Purification

Purified by antigen affinity column.

Numéro d'accès

P11940

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Polyadenylate-binding protein 1 (PABPC1) is a ~70 kDa protein. Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Involved in translationally coupled mRNA turnover.

1. Grosset, C. et al. (2000) Cell 103, 29-40. PMID: 11051545

2. Patel, GP. et al. (2006) The FEBS journal 273, 5678-90. PMID: 17212783

3. Lim, J. et al. (2014) Cell 159, 1365-76. PMID: 25480299

4. Schäffler, K. et al. (2010) RNA (New York, N.Y.) 16, 1488-99. PMID: 20573744

5. Zhu, S. et al. (2020) Nature communications 11, 1685. PMID: 32245947

6. Singh, G. et al. (2008) PLoS biology 6, e111. PMID: 18447585

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human PABPC1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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