Anti-Human PDK1 Recombinant Antibody (SAA1680) (HS822013)

Name: Anti-Human PDK1 Recombinant Antibody (SAA1680)
Brand: abinScience
SKU: HS822013
Price: 196 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HS822013

Reactividad de especies

Human

Aplicaciones

ELISA

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG2a, kappa

ID de clon

SAA1680

Objetivo

PDHK1, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial, PDK1, Pyruvate dehydrogenase kinase isoform 1, PDH kinase 1

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

Q15118

RRID

Anti-Human PDK1 Antibody (SAA1680) (abinScience Cat# HS822013, RRID:AB_3727441)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) is a ~49 kDa protein. Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia.

1. Gudi, R. et al. (1995) The Journal of biological chemistry 270, 28989-94. PMID: 7499431

2. McFate, T. et al. (2008) The Journal of biological chemistry 283, 22700-8. PMID: 18541534

3. Hitosugi, T. et al. (2011) Molecular cell 44, 864-77. PMID: 22195962

4. Li, X. et al. (2016) Molecular cell 61, 705-719. PMID: 26942675

5. Kato, M. et al. (2007) Structure (London, England : 1993) 15, 992-1004. PMID: 17683942

Nota

For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human PDK1 Antibody (SAA1680)

Referencias

Datasheet

Anti-Human PDK1 Recombinant Antibody (SAA1680).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo