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| カタログ番号 | HS822013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1680 | ||||
| ターゲット | PDHK1, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial, PDK1, Pyruvate dehydrogenase kinase isoform 1, PDH kinase 1 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q15118 | ||||
| RRID | Anti-Human PDK1 Antibody (SAA1680) (abinScience Cat# HS822013, RRID:AB_3727441) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
| ||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) is a ~49 kDa protein. Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. 1. Gudi, R. et al. (1995) The Journal of biological chemistry 270, 28989-94. PMID: 7499431 2. McFate, T. et al. (2008) The Journal of biological chemistry 283, 22700-8. PMID: 18541534 3. Hitosugi, T. et al. (2011) Molecular cell 44, 864-77. PMID: 22195962 4. Li, X. et al. (2016) Molecular cell 61, 705-719. PMID: 26942675 5. Kato, M. et al. (2007) Structure (London, England : 1993) 15, 992-1004. PMID: 17683942 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human PDK1 Antibody (SAA1680)
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