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| カタログ番号 | HF951013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1529 | ||||
| ターゲット | Peptidoglycan recognition protein 1, PGLYRP, PGRP, Peptidoglycan recognition protein short, TNFSF3L, PGRP-S, PGLYRP1 | ||||
| エンドトキシンレベル | < 10 EU/mg | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | O75594 | ||||
| RRID | Anti-Human PGLYRP1 Antibody (SAA1529) (abinScience Cat# HF951013, RRID:AB_3727290) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Peptidoglycan recognition protein 1 (PGLYRP1) is a ~21 kDa protein. Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity. Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system. 1. Kang, D. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 10078-82. PMID: 9707603 2. Yashin, DV. et al. (2011) The Journal of biological chemistry 286, 10258-64. PMID: 21247889 3. Yashin, DV. et al. (2015) The Journal of biological chemistry 290, 21724-31. PMID: 26183779 4. Dukhanina, EA. et al. (2015) Cell cycle (Georgetown, Tex.) 14, 3635-43. PMID: 26654597 5. Sharapova, TN. et al. (2018) Acta naturae 10, 115-120. PMID: 30713770 6. Sharapova, TN. et al. (2017) Journal of innate immunity 9, 598-608. PMID: 28977785 7. Sharapova, TN. et al. (2017) IUBMB life 69, 971-977. PMID: 29083508 8. Read, CB. et al. (2015) Journal of immunology (Baltimore, Md. : 1950) 194, 1417-21. PMID: 25595774 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human PGLYRP1 Antibody (SAA1529)
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