Anti-Human PGLYRP1 Polyclonal Antibody (HF951014)

Name: Anti-Human PGLYRP1 Polyclonal Antibody
Brand: abinScience
SKU: HF951014
Price: 168 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HF951014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PGLYRP1 (Gln22-Pro196).

Target

Peptidoglycan recognition protein 1, PGLYRP, PGRP, Peptidoglycan recognition protein short, TNFSF3L, PGRP-S, PGLYRP1

Purification

Purified by antigen affinity column.

Accession

O75594

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Peptidoglycan recognition protein 1 (PGLYRP1) is a ~21 kDa protein. Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity. Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system.

1. Kang, D. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 10078-82. PMID: 9707603

2. Yashin, DV. et al. (2011) The Journal of biological chemistry 286, 10258-64. PMID: 21247889

3. Yashin, DV. et al. (2015) The Journal of biological chemistry 290, 21724-31. PMID: 26183779

4. Dukhanina, EA. et al. (2015) Cell cycle (Georgetown, Tex.) 14, 3635-43. PMID: 26654597

5. Sharapova, TN. et al. (2018) Acta naturae 10, 115-120. PMID: 30713770

6. Sharapova, TN. et al. (2017) Journal of innate immunity 9, 598-608. PMID: 28977785

7. Sharapova, TN. et al. (2017) IUBMB life 69, 971-977. PMID: 29083508

8. Read, CB. et al. (2015) Journal of immunology (Baltimore, Md. : 1950) 194, 1417-21. PMID: 25595774

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Human PGLYRP1 polyclonal antibody at 1ug/mL on recombinant Human PGLYRP1 (Catalog No. HF951012).

References

Datasheet