Anti-Human PIP4K2A Polyclonal Antibody (HD637014)

Name: Anti-Human PIP4K2A Polyclonal Antibody
Brand: abinScience
SKU: HD637014
Price: 168 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HD637014

説明

Anti-Human PIP4K2A Polyclonal Antibody (HD637014) is a rabbit polyclonal antibody detecting PIP4K2A. Suitable for Human, Rat, and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

種反応性

Human, Mouse, Rat

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human PIP4K2A (Ser34-Thr406).

ターゲット

1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha, Diphosphoinositide kinase 2-alpha, EC:2.7.1.149, PI(5)P 4-kinase type II alpha, PI5P4KA, PI5P4Kalpha, PIP4K2A, PIP4KII-alpha, PIP5K2, PIP5K2A, PIP5KIII, Phosphatidylinositol 5-Phosphate 4-Kinase, Phosphatidylinositol 5-phosphate 4-kinase type II alpha, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, PtdIns(4)P-5-kinase B isoform, PtdIns(4)P-5-kinase C isoform, PtdIns(5)P-4-kinase isoform 2-alpha

エンドトキシンレベル

Please contact with the lab for this information.

精製

Purified by antigen affinity column.

アクセッション番号

P48426

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a ~46 kDa protein. Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Has both ATP- and GTP-dependent kinase activities. May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level.

1. Davis, MI. et al. (2013) PloS one 8, e54127. PMID: 23326584

2. Rameh, LE. et al. (1997) Nature 390, 192-6. PMID: 9367159

3. Sumita, K. et al. (2016) Molecular cell 61, 187-98. PMID: 26774281

4. Wilcox, A. et al. (2008) FEBS letters 582, 1391-4. PMID: 18364242

5. Hu, A. et al. (2018) Journal of lipid research 59, 507-514. PMID: 29353240

6. Wang, DG. et al. (2019) Cell reports 27, 1991-2001.e5. PMID: 31091439

注意事項

For research use only

イメージ

参考文献

データシート

Anti-Human PIP4K2A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-Human PIP4K2A Polyclonal Antibody (HD637014)

概要

イメージ

参考文献

データシート

SDS