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| カタログ番号 | HD558014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human POLD4 Polyclonal Antibody (HD558014) is a rabbit polyclonal antibody detecting POLD4. Suitable for Human.
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human POLD4 (Glu45-Leu107). | ||||||||
| ターゲット | DNA polymerase delta subunit 4, DNA polymerase delta subunit p12, POLD4, POLDS | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9HCU8 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | DNA polymerase delta subunit 4 (POLD4) is a ~12 kDa protein. As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity. Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb. Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites. 1. Li, H. et al. (2006) The Journal of biological chemistry 281, 14748-55. PMID: 16510448 2. Meng, X. et al. (2009) Nucleic acids research 37, 647-57. PMID: 19074196 3. Meng, X. et al. (2010) Biochemistry 49, 3545-54. PMID: 20334433 4. Lin, SH. et al. (2013) DNA repair 12, 922-35. PMID: 24035200 5. Costantino, L. et al. (2014) Science (New York, N.Y.) 343, 88-91. PMID: 24310611 6. Terai, K. et al. (2013) The Journal of biological chemistry 288, 30509-30514. PMID: 24022480 | ||||||||
| 注意事項 | For research use only |
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