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| カタログ番号 | HW821025 |
|---|---|
| 説明 |
Anti-Human PSEN2 Monoclonal Antibody (1A530) [1A530] (HW821025) is a mouse monoclonal antibody detecting PSEN2 in ELISA, IHC, WB. Suitable for Human.
Highlights
|
| 種反応性 | Human |
| アプリケーション | ELISA, IHC, WB |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG |
| クローンID | 1A530 |
| 免疫原 | E. coli - derived recombinant human PSEN2 (Lys271-Lys361). |
| ターゲット | Presenilin-2, PS-2, EC:3.4.23.-, AD3LP, AD5, E5-1, STM-2, Presenilin-2 NTF subunit, Presenilin-2 CTF subunit, PSEN2 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P49810 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Presenilin-2 (PSEN2) is a ~50 kDa protein. Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular amyloid beta that contains longer amyloid beta. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria. 1. Steiner, H. et al. (1999) The Journal of biological chemistry 274, 28669-73. PMID: 10497236 2. Kimberly, WT. et al. (2000) The Journal of biological chemistry 275, 3173-8. PMID: 10652302 3. Kumar-Singh, S. et al. (2006) Human mutation 27, 686-95. PMID: 16752394 4. Sannerud, R. et al. (2016) Cell 166, 193-208. PMID: 27293189 5. Guo, X. et al. (2022) Nature communications 13, 6299. PMID: 36272978 6. Tu, H. et al. (2006) Cell 126, 981-93. PMID: 16959576 7. Zampese, E. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2777-82. PMID: 21285369 |
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human PSEN2 Monoclonal Antibody (1A530)
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