Anti-Human PSEN2/Presenilin-2 Recombinant Antibody (SAA1783) (HW821013)

Name: Anti-Human PSEN2/Presenilin-2 Recombinant Antibody (SAA1783)
Brand: abinScience
SKU: HW821013
Price: 196 USD
Availability: InStock

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100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HW821013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1783

Clonality

Monoclonal

Target

PSEN2, PS-2, AD4, PS2, AD3LP, STM2, E5-1, STM-2, Presenilin-2, AD5, PSNL2

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P49810

RRID

Anti-Human PSEN2/Presenilin-2 Antibody (SAA1783) (abinScience Cat# HW821013, RRID:AB_3727545)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Presenilin-2 (PSEN2) is a ~50 kDa protein. Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular amyloid beta that contains longer amyloid beta. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.

1. Steiner, H. et al. (1999) The Journal of biological chemistry 274, 28669-73. PMID: 10497236

2. Kimberly, WT. et al. (2000) The Journal of biological chemistry 275, 3173-8. PMID: 10652302

3. Kumar-Singh, S. et al. (2006) Human mutation 27, 686-95. PMID: 16752394

4. Sannerud, R. et al. (2016) Cell 166, 193-208. PMID: 27293189

5. Guo, X. et al. (2022) Nature communications 13, 6299. PMID: 36272978

6. Tu, H. et al. (2006) Cell 126, 981-93. PMID: 16959576

7. Zampese, E. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2777-82. PMID: 21285369

Note

For research use only.

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