Anti-Human PSEN2 Monoclonal Antibody (1A530) (HW821025)

Name: Anti-Human PSEN2 Monoclonal Antibody (1A530)
Brand: abinScience
SKU: HW821025
Price: 106 USD
Availability: InStock

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Overview

Catalog No.	HW821025
Description	Anti-Human PSEN2 Monoclonal Antibody (1A530) [1A530] (HW821025) is a mouse monoclonal antibody detecting PSEN2 in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, IHC, WB
Host species	Mouse
Isotype	IgG
Clone ID	1A530
Clonality	Monoclonal
Immunogen	E. coli - derived recombinant human PSEN2 (Lys271-Lys361).
Target	Presenilin-2, PS-2, EC:3.4.23.-, AD3LP, AD5, E5-1, STM-2, Presenilin-2 NTF subunit, Presenilin-2 CTF subunit, PSEN2
Purification	Protein A/G purified from cell culture supernatant.
Accession	P49810
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Presenilin-2 (PSEN2) is a ~50 kDa protein. Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular amyloid beta that contains longer amyloid beta. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria. 1. Steiner, H. et al. (1999) The Journal of biological chemistry 274, 28669-73. PMID: 10497236 2. Kimberly, WT. et al. (2000) The Journal of biological chemistry 275, 3173-8. PMID: 10652302 3. Kumar-Singh, S. et al. (2006) Human mutation 27, 686-95. PMID: 16752394 4. Sannerud, R. et al. (2016) Cell 166, 193-208. PMID: 27293189 5. Guo, X. et al. (2022) Nature communications 13, 6299. PMID: 36272978 6. Tu, H. et al. (2006) Cell 126, 981-93. PMID: 16959576 7. Zampese, E. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2777-82. PMID: 21285369
Note	For research use only.