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| カタログ番号 | HF617013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1504 | ||||
| ターゲット | Receptor activity-modifying protein 3, Calcitonin-receptor-like receptor activity-modifying protein 3, RAMP3, CRLR activity-modifying protein 3 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | O60896 | ||||
| RRID | Anti-Human RAMP3 Antibody (SAA1504) (abinScience Cat# HF617013, RRID:AB_3727265) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Receptor activity-modifying protein 3 (RAMP3) is a ~16 kDa protein. Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G-protein coupled estrogen receptor 1 (GPER1). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane. Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2. Together with CALCR, act as a receptor complex for amylin/IAPP. 1. Lenhart, PM. et al. (2013) Journal of molecular endocrinology 51, 191-202. PMID: 23674134 2. McLatchie, LM. et al. (1998) Nature 393, 333-9. PMID: 9620797 3. Liang, YL. et al. (2020) ACS pharmacology & translational science 3, 263-284. PMID: 32296767 4. Cao, J. et al. (2022) Science (New York, N.Y.) 375, eabm9609. PMID: 35324283 | ||||
| 注意事項 | For research use only. | ||||
| Isotype Control | Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023) |
SDS-PAGE for Anti-Human RAMP3 Antibody (SAA1504).
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