中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HP312014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human RB1CC1 Polyclonal Antibody (HP312014) is a rabbit polyclonal antibody detecting RB1CC1 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
|
||||||||
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RB1CC1 (Glu1447-Val1594). | ||||||||
| ターゲット | FAK family kinase-interacting protein of 200 kDa, RB1CC1, FIP200, RBICC, RB1-inducible coiled-coil protein 1, KIAA0203 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q8TDY2 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | RB1-inducible coiled-coil protein 1 (RB1CC1) is a ~183 kDa protein. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. 1. Morselli, E. et al. (2011) Cell cycle (Georgetown, Tex.) 10, 2763-9. PMID: 21775823 2. Nishimura, T. et al. (2013) EMBO reports 14, 284-91. PMID: 23392225 3. Ueda, H. et al. (2000) The Journal of cell biology 149, 423-30. PMID: 10769033 4. Abbi, S. et al. (2002) Molecular biology of the cell 13, 3178-91. PMID: 12221124 5. Chano, T. et al. (2002) Gene 291, 29-34. PMID: 12095676 6. Kontani, K. et al. (2003) International journal of molecular medicine 12, 767-9. PMID: 14533007 7. Chano, T. et al. (2002) The American journal of pathology 161, 359-64. PMID: 12163359 | ||||||||
| 注意事項 | For research use only. |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
