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| カタログ番号 | HP909014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RBCK1 (Met1-Gly156). | ||||||||
| ターゲット | RING finger protein 54, RNF54, RanBP-type and C3HC4-type zinc finger-containing protein 1, C20orf18, XAP4 X-associated protein 4, UBCE7IP3, RBCK1, RING-type E3 ubiquitin transferase HOIL-1, HOIL-1, Heme-oxidized IRP2 ubiquitin ligase 1, XAP3, Ubiquitin-conjugating enzyme 7-interacting protein 3, HBV-associated factor 4 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9BYM8 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1) is a ~57 kDa protein. E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. 1. Yamanaka, K. et al. (2003) Nature cell biology 5, 336-40. PMID: 12629548 2. Tian, Y. et al. (2007) The Journal of biological chemistry 282, 16776-82. PMID: 17449468 3. Zhang, M. et al. (2008) Cell research 18, 1096-104. PMID: 18711448 4. Kirisako, T. et al. (2006) The EMBO journal 25, 4877-87. PMID: 17006537 5. Tokunaga, F. et al. (2009) Nature cell biology 11, 123-32. PMID: 19136968 6. Gerlach, B. et al. (2011) Nature 471, 591-6. PMID: 21455173 7. Tokunaga, F. et al. (2011) Nature 471, 633-6. PMID: 21455180 8. Ikeda, F. et al. (2011) Nature 471, 637-41. PMID: 21455181 9. Noad, J. et al. (2017) Nature microbiology 2, 17063. PMID: 28481331 | ||||||||
| 注意事項 | For research use only. |
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