Anti-Human RBCK1 Polyclonal Antibody (HP909014)

Name: Anti-Human RBCK1 Polyclonal Antibody
Brand: abinScience
SKU: HP909014
Price: 168 USD
Availability: InStock

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Обзор
Изображения
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Даташит
SDS

Обзор

Каталожный номер

HP909014

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human RBCK1 (Met1-Gly156).

Цель

RING finger protein 54, RNF54, RanBP-type and C3HC4-type zinc finger-containing protein 1, C20orf18, XAP4 X-associated protein 4, UBCE7IP3, RBCK1, RING-type E3 ubiquitin transferase HOIL-1, HOIL-1, Heme-oxidized IRP2 ubiquitin ligase 1, XAP3, Ubiquitin-conjugating enzyme 7-interacting protein 3, HBV-associated factor 4

Очистка

Purified by antigen affinity column.

Номер доступа

Q9BYM8

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1) is a ~57 kDa protein. E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways.

1. Yamanaka, K. et al. (2003) Nature cell biology 5, 336-40. PMID: 12629548

2. Tian, Y. et al. (2007) The Journal of biological chemistry 282, 16776-82. PMID: 17449468

3. Zhang, M. et al. (2008) Cell research 18, 1096-104. PMID: 18711448

4. Kirisako, T. et al. (2006) The EMBO journal 25, 4877-87. PMID: 17006537

5. Tokunaga, F. et al. (2009) Nature cell biology 11, 123-32. PMID: 19136968

6. Gerlach, B. et al. (2011) Nature 471, 591-6. PMID: 21455173

7. Tokunaga, F. et al. (2011) Nature 471, 633-6. PMID: 21455180

8. Ikeda, F. et al. (2011) Nature 471, 637-41. PMID: 21455181

9. Noad, J. et al. (2017) Nature microbiology 2, 17063. PMID: 28481331

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human RBCK1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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