

| Número de catálogo | HP302014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reactividad de especies | Human, Mouse, Rat | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human RBM24 (Thr11-Lys91). | ||||||||
| Objetivo | RNA-binding region-containing protein 6, RNA-binding protein 24, RNA-binding motif protein 24, RBM24, RNPC6 | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | Q9BX46 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | RNA-binding protein 24 (RBM24) is a ~24 kDa protein. Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes. 1. Jin, D. et al. (2010) Genes to cells : devoted to molecular & cellular mechanisms 15, 1158-67. PMID: 20977548 2. Xu, E. et al. (2014) Molecular cancer research : MCR 12, 359-69. PMID: 24375645 3. Lin, Y. et al. (2018) The international journal of biochemistry & cell biology 94, 10-21. PMID: 29104163 4. Zhang, M. et al. (2018) Cell death and differentiation 25, 1118-1130. PMID: 29358667 5. Zhang, T. et al. (2016) Stem cells (Dayton, Ohio) 34, 1776-89. PMID: 26990106 6. Jiang, Y. et al. (2014) The Journal of biological chemistry 289, 3164-75. PMID: 24356969 | ||||||||
| Nota | For research use only. |


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