

| Número de catálogo | HP322014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Descripción |
Anti-Human RBPMS Polyclonal Antibody (HP322014) is a rabbit polyclonal antibody detecting RBPMS in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| Reactividad de especies | Human, Mouse, Rat | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human RBPMS (Glu22-Glu97). | ||||||||
| Objetivo | Hermes, Heart and RRM expressed sequence, RNA-binding protein with multiple splicing, HERMES, RBP-MS, RBPMS | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | Q93062 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | RNA-binding protein with multiple splicing (RBPMS) is a ~21 kDa protein. RNA binding protein that mediates the regulation of pre-mRNA alternative splicing (AS). Acts either as activator (FLNB, HSPG2, LIPA1, MYOCD, PTPRF and PPFIBP1) or repressor (TPM1, ACTN1, ITGA7, PIEZO1, LSM14B, MBNL1 and MBML2) of splicing events on specific pre-mRNA targets. Together with RNA binding proteins RBFOX2 and MBNL1/2, activates a splicing program associated with differentiated contractile vascular smooth muscle cells (SMC) by regulating AS of numerous pre-mRNA involved in actin cytoskeleton and focal adhesion machineries, suggesting a role in promoting a cell differentiated state. Binds to introns, exons and 3'-UTR associated with tandem CAC trinucleotide motifs separated by a variable spacer region, at a minimum as a dimer. The minimal length of RNA required for RBPMS-binding tandem CAC motifs is 15 nt, with spacing ranging from 1 to 9 nt. 1. Farazi, TA. et al. (2014) RNA (New York, N.Y.) 20, 1090-102. PMID: 24860013 2. Teplova, M. et al. (2016) Quarterly reviews of biophysics 49, e1. PMID: 26347403 | ||||||||
| Nota | For research use only. |


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