Human RBPMS Recombinant Protein (N-GST & C-His) (HP322022)

Name: Human RBPMS Recombinant Protein (N-GST & C-His)
Brand: abinScience
SKU: HP322022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HP322022
Description	Recombinant Human RBPMS Protein, N-GST & C-His (HP322022) expressed in E. coli, spanning Glu22-Glu97. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q93062
Protein length	Glu22-Glu97
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	36.79 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	HERMES, Heart and RRM expressed sequence, Hermes, RBP-MS, RBPMS, RNA-binding protein with multiple splicing
Background	RNA-binding protein with multiple splicing is a ~21 kDa protein. RNA binding protein that mediates the regulation of pre-mRNA alternative splicing (AS). Acts either as activator (FLNB, HSPG2, LIPA1, MYOCD, PTPRF and PPFIBP1) or repressor (TPM1, ACTN1, ITGA7, PIEZO1, LSM14B, MBNL1 and MBML2) of splicing events on specific pre-mRNA targets. Together with RNA binding proteins RBFOX2 and MBNL1/2, activates a splicing program associated with differentiated contractile vascular smooth muscle cells (SMC) by regulating AS of numerous pre-mRNA involved in actin cytoskeleton and focal adhesion machineries, suggesting a role in promoting a cell differentiated state. Binds to introns, exons and 3'-UTR associated with tandem CAC trinucleotide motifs separated by a variable spacer region, at a minimum as a dimer. The minimal length of RNA required for RBPMS-binding tandem CAC motifs is 15 nt, with spacing ranging from 1 to 9 nt. 1. Farazi, TA. et al. (2014) RNA (New York, N.Y.) 20, 1090-102. PMID: 24860013 2. Teplova, M. et al. (2016) Quarterly reviews of biophysics 49, e1. PMID: 26347403
Note	For research use only

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Datasheet

Human RBPMS Recombinant Protein (N-GST & C-His).pdf

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Human RBPMS Recombinant Protein (N-GST & C-His) (HP322022)

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