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Anti-Human RCC1 Polyclonal Antibody (HD651014)

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Aperçu
Numéro de catalogueHD651014
Description
Anti-Human RCC1 Polyclonal Antibody (HD651014) is a rabbit polyclonal antibody detecting RCC1. Suitable for Mouse and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human RCC1 (Val37-Ser421).
Cible CHC1, Cell cycle regulatory protein, Chromosome condensation protein 1, RCC1, Regulator of chromosome condensation
Niveau d'endotoxines Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Numéro d'accès P18754
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Contexte

Regulator of chromosome condensation (RCC1) is a ~44 kDa protein. Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA.

1. Renault, L. et al. (2001) Cell 105, 245-55. PMID: 11336674
2. Chen, T. et al. (2007) Nature cell biology 9, 596-603. PMID: 17435751
3. Bischoff, FR. et al. (1991) Nature 354, 80-2. PMID: 1944575
4. Tooley, CE. et al. (2010) Nature 466, 1125-8. PMID: 20668449
5. Halpin, D. et al. (2011) PLoS biology 9, e1001225. PMID: 22215983
6. Sankhala, RS. et al. (2017) Nature communications 8, 979. PMID: 29042532
7. Moore, W. et al. (2002) Current biology : CB 12, 1442-7. PMID: 12194828
Note For research use only
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Fiche technique
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human RCC1 Polyclonal Antibody

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