Human RCC1 Recombinant Protein (N-His) (HD651012)

Name: Human RCC1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD651012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD651012
Description	Recombinant Human RCC1 Protein, N-His (HD651012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	P18754
Protein length	Val37-Ser421
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CHC1, Cell cycle regulatory protein, Chromosome condensation protein 1, RCC1, Regulator of chromosome condensation
Background	Regulator of chromosome condensation is a ~44 kDa protein. Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. 1. Renault, L. et al. (2001) Cell 105, 245-55. PMID: 11336674 2. Chen, T. et al. (2007) Nature cell biology 9, 596-603. PMID: 17435751 3. Bischoff, FR. et al. (1991) Nature 354, 80-2. PMID: 1944575 4. Tooley, CE. et al. (2010) Nature 466, 1125-8. PMID: 20668449 5. Halpin, D. et al. (2011) PLoS biology 9, e1001225. PMID: 22215983 6. Sankhala, RS. et al. (2017) Nature communications 8, 979. PMID: 29042532 7. Moore, W. et al. (2002) Current biology : CB 12, 1442-7. PMID: 12194828
Note	For research use only

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Datasheet

Human RCC1 Recombinant Protein (N-His).pdf

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Human RCC1 Recombinant Protein (N-His) (HD651012)

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