Anti-Human RCC1 Polyclonal Antibody (HD651014)

Name: Anti-Human RCC1 Polyclonal Antibody
Brand: abinScience
SKU: HD651014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HD651014

Description

Anti-Human RCC1 Polyclonal Antibody (HD651014) is a rabbit polyclonal antibody detecting RCC1. Suitable for Mouse and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human RCC1 (Val37-Ser421).

Target

CHC1, Cell cycle regulatory protein, Chromosome condensation protein 1, RCC1, Regulator of chromosome condensation

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P18754

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Regulator of chromosome condensation (RCC1) is a ~44 kDa protein. Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA.

1. Renault, L. et al. (2001) Cell 105, 245-55. PMID: 11336674

2. Chen, T. et al. (2007) Nature cell biology 9, 596-603. PMID: 17435751

3. Bischoff, FR. et al. (1991) Nature 354, 80-2. PMID: 1944575

4. Tooley, CE. et al. (2010) Nature 466, 1125-8. PMID: 20668449

5. Halpin, D. et al. (2011) PLoS biology 9, e1001225. PMID: 22215983

6. Sankhala, RS. et al. (2017) Nature communications 8, 979. PMID: 29042532

7. Moore, W. et al. (2002) Current biology : CB 12, 1442-7. PMID: 12194828

Note

For research use only

Images

References

Datasheet

Anti-Human RCC1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human RCC1 Polyclonal Antibody (HD651014)

Overview

Images

References

Datasheet

SDS

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