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| カタログ番号 | HD651014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human RCC1 Polyclonal Antibody (HD651014) is a rabbit polyclonal antibody detecting RCC1. Suitable for Mouse and Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RCC1 (Val37-Ser421). | ||||||||
| ターゲット | CHC1, Cell cycle regulatory protein, Chromosome condensation protein 1, RCC1, Regulator of chromosome condensation | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P18754 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Regulator of chromosome condensation (RCC1) is a ~44 kDa protein. Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. 1. Renault, L. et al. (2001) Cell 105, 245-55. PMID: 11336674 2. Chen, T. et al. (2007) Nature cell biology 9, 596-603. PMID: 17435751 3. Bischoff, FR. et al. (1991) Nature 354, 80-2. PMID: 1944575 4. Tooley, CE. et al. (2010) Nature 466, 1125-8. PMID: 20668449 5. Halpin, D. et al. (2011) PLoS biology 9, e1001225. PMID: 22215983 6. Sankhala, RS. et al. (2017) Nature communications 8, 979. PMID: 29042532 7. Moore, W. et al. (2002) Current biology : CB 12, 1442-7. PMID: 12194828 | ||||||||
| 注意事項 | For research use only |
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