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| カタログ番号 | HX184014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human RHOA Polyclonal Antibody (HX184014) is a rabbit polyclonal antibody detecting RHOA in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RHOA (Ala2-Gly189). | ||||||||
| ターゲット | Rho cDNA clone 12, ARH12, RHO12, ARHA, RHOA, Transforming protein RhoA, h12 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P61586 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Transforming protein RhoA is a ~21 kDa protein. Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. 1. Wei, J. et al. (2013) Biochimica et biophysica acta 1833, 2757-2764. PMID: 23871831 2. Vabres, P. et al. (2019) Nature genetics 51, 1438-1441. PMID: 31570889 3. Quilliam, LA. et al. (1996) The Journal of biological chemistry 271, 28772-6. PMID: 8910519 4. Vincent, S. et al. (1997) Molecular and cellular biology 17, 2247-56. PMID: 9121475 5. Wing, MR. et al. (2003) The Journal of biological chemistry 278, 41253-8. PMID: 12900402 6. Kamijo, K. et al. (2006) Molecular biology of the cell 17, 43-55. PMID: 16236794 7. Wallace, SW. et al. (2011) Molecular and cellular biology 31, 81-91. PMID: 20974804 8. Dubash, AD. et al. (2013) The Journal of cell biology 202, 653-66. PMID: 23940119 9. Bristow, JM. et al. (2009) Journal of cell science 122, 4535-46. PMID: 19934221 10. Zaoui, K. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 18517-22. PMID: 20937854 | ||||||||
| 注意事項 | For research use only. |
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