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| カタログ番号 | HC711014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human RNF31 Polyclonal Antibody (HC711014) is a rabbit polyclonal antibody detecting RNF31. Suitable for Human.
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RNF31 (Met1-Lys181). | ||||||||
| ターゲット | E3 ubiquitin-protein ligase RNF31, EC:2.3.2.31, HOIL-1-interacting protein, HOIP, RING finger protein 31, RING-type E3 ubiquitin transferase RNF31, RNF31, ZIBRA, Zinc in-between-RING-finger ubiquitin-associated domain protein | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q96EP0 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | E3 ubiquitin-protein ligase RNF31 is a ~119 kDa protein. E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria. 1. Kirisako, T. et al. (2006) The EMBO journal 25, 4877-87. PMID: 17006537 2. Tokunaga, F. et al. (2009) Nature cell biology 11, 123-32. PMID: 19136968 3. Haas, TL. et al. (2009) Molecular cell 36, 831-44. PMID: 20005846 4. Gerlach, B. et al. (2011) Nature 471, 591-6. PMID: 21455173 5. Tokunaga, F. et al. (2011) Nature 471, 633-6. PMID: 21455180 6. Ikeda, F. et al. (2011) Nature 471, 637-41. PMID: 21455181 7. Smit, JJ. et al. (2012) The EMBO journal 31, 3833-44. PMID: 22863777 8. Goto, E. et al. (2017) Biochemical and biophysical research communications 485, 152-159. PMID: 28189684 9. Noad, J. et al. (2017) Nature microbiology 2, 17063. PMID: 28481331 10. Schlicher, L. et al. (2016) EMBO reports 17, 1485-1497. PMID: 27458237 | ||||||||
| 注意事項 | For research use only |
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