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| カタログ番号 | HY562013 | ||||||
|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||
| アプリケーション | ELISA, FCM, WB | ||||||
| 宿主種 | Mouse | ||||||
| クローン性 | Monoclonal | ||||||
| アイソタイプ | IgG2a, kappa | ||||||
| クローンID | 6B4 | ||||||
| ターゲット | Protein S100-A9, CAGB, MRP-14, S100 calcium-binding protein A9, Leukocyte L1 complex heavy chain, Migration inhibitory factor-related protein 14, p14, Calprotectin L1H subunit, S100A9, Calgranulin-B, CFAG, MRP14 | ||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||||
| アクセッション番号 | P06702 | ||||||
| RRID | Anti-Human S100A9 Antibody (6B4) (abinScience Cat# HY562013, RRID:AB_3726893) |
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| 形態 | Liquid | ||||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||||
| 背景 | Protein S100-A9 (S100A9) is a ~13 kDa protein. S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Also participates in regulatory T-cell differentiation together with CD69. _x005F_x005F_x000D_ _x005F_x005F_x000D_1. Ryckman, C. et al. (2003) Journal of immunology (Baltimore, Md. : 1950) 170, 3233-42. PMID: 12626582 _x005F_x005F_x000D_
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2. Vogl, T. et al. (2004) Blood 104, 4260-8. PMID: 15331440 _x005F_x005F_x000D_
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3. Nakatani, Y. et al. (2005) Mediators of inflammation 2005, 280-92. PMID: 16258195 _x005F_x005F_x000D_
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4. Champaiboon, C. et al. (2009) The Journal of biological chemistry 284, 7078-90. PMID: 19122197 _x005F_x005F_x000D_
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5. Simard, JC. et al. (2010) Journal of leukocyte biology 87, 905-14. PMID: 20103766 _x005F_x005F_x000D_
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6. Simard, JC. et al. (2011) Journal of immunology (Baltimore, Md. : 1950) 186, 3622-31. PMID: 21325622 _x005F_x005F_x000D_
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7. Miyasaki, KT. et al. (1993) Journal of dental research 72, 517-23. PMID: 8423249 _x005F_x005F_x000D_
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8. Lin, CR. et al. (2015) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 29, 5006-17. PMID: 26296369 | ||||||
| 注意事項 | For research use only. | ||||||
| Isotype Control | Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023) |
Detects Recombinant Human S100A9 Protein, N-His (Cat No.: HY562012) in indirect ELISA.
SDS-PAGE for Anti-Human S100A9 Antibody (6B4).
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