

| Каталожный номер | HD581014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human SAMTOR Polyclonal Antibody (HD581014) is a rabbit polyclonal antibody detecting SAMTOR. Suitable for Human and Mouse.
Highlights
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| Реактивность видов | Human, Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human SAMTOR (Glu34-Asn354). | ||||||||
| Цель | BMT2, C7orf60, EC:2.1.1.-, Probable methyltransferase BMT2 homolog, S-adenosylmethionine sensor upstream of mTORC1, SAMTOR | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q1RMZ1 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Фон | S-adenosylmethionine sensor upstream of mTORC1 (SAMTOR) is a ~46 kDa protein. S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential). 1. Gu, X. et al. (2017) Science (New York, N.Y.) 358, 813-818. PMID: 29123071 2. Tang, X. et al. (2022) Science advances 8, eabn3868. PMID: 35776786 | ||||||||
| Примечание | For research use only |
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