Human SAMTOR Recombinant Protein (N-His) (HD581012)

Name: Human SAMTOR Recombinant Protein (N-His)
Brand: abinScience
SKU: HD581012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD581012
Description	Recombinant Human SAMTOR Protein, N-His (HD581012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q1RMZ1
Protein length	Glu34-Asn354
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	BMT2, C7orf60, EC:2.1.1.-, Probable methyltransferase BMT2 homolog, S-adenosylmethionine sensor upstream of mTORC1, SAMTOR
Background	S-adenosylmethionine sensor upstream of mTORC1 is a ~46 kDa protein. S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential). 1. Gu, X. et al. (2017) Science (New York, N.Y.) 358, 813-818. PMID: 29123071 2. Tang, X. et al. (2022) Science advances 8, eabn3868. PMID: 35776786
Note	For research use only

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Datasheet

Human SAMTOR Recombinant Protein (N-His).pdf

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Human SAMTOR Recombinant Protein (N-His) (HD581012)

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