Anti-Human SAMTOR Polyclonal Antibody (HD581014)

Name: Anti-Human SAMTOR Polyclonal Antibody
Brand: abinScience
SKU: HD581014
Price: 168 USD
Availability: InStock

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Overview
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Datasheet
SDS

Overview

Catalog No.

HD581014

Description

Anti-Human SAMTOR Polyclonal Antibody (HD581014) is a rabbit polyclonal antibody detecting SAMTOR. Suitable for Human and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SAMTOR (Glu34-Asn354).

Target

BMT2, C7orf60, EC:2.1.1.-, Probable methyltransferase BMT2 homolog, S-adenosylmethionine sensor upstream of mTORC1, SAMTOR

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q1RMZ1

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

S-adenosylmethionine sensor upstream of mTORC1 (SAMTOR) is a ~46 kDa protein. S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential).

1. Gu, X. et al. (2017) Science (New York, N.Y.) 358, 813-818. PMID: 29123071

2. Tang, X. et al. (2022) Science advances 8, eabn3868. PMID: 35776786

Note

For research use only

Images

References

Datasheet

Anti-Human SAMTOR Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human SAMTOR Polyclonal Antibody (HD581014)

Overview

Images

References

Datasheet

SDS

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