Anti-Human SARM1 Polyclonal Antibody (HD538014)

Name: Anti-Human SARM1 Polyclonal Antibody
Brand: abinScience
SKU: HD538014
Price: 168 USD
Availability: InStock

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50ug
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Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HD538014

Descripción

Anti-Human SARM1 Polyclonal Antibody (HD538014) is a rabbit polyclonal antibody detecting SARM1. Suitable for Human, Rat, and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human SARM1 (Gly56-Gly398).

Objetivo

EC:3.2.2.-, EC:3.2.2.6, HsTIR, KIAA0524, MyD88-5, NAD(+) hydrolase SARM1, NADP(+) hydrolase SARM1, NADase SARM1, SAM domain-containing protein 2, SAMD2, SARM, SARM1, Sterile alpha and Armadillo repeat protein, Sterile alpha and TIR motif-containing protein 1, Sterile alpha motif domain-containing protein 2, Tir-1 homolog, hSARM1

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

Q6SZW1

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Fondo

NAD(+) hydrolase SARM1 is a ~79 kDa protein. NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules. Can activate neuronal cell death in response to stress.

1. Gerdts, J. et al. (2015) Science (New York, N.Y.) 348, 453-7. PMID: 25908823

2. Summers, DW. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, E6271-E6280. PMID: 27671644

3. Essuman, K. et al. (2017) Neuron 93, 1334-1343.e5. PMID: 28334607

4. Liberati, NT. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 6593-8. PMID: 15123841

5. Carty, M. et al. (2006) Nature immunology 7, 1074-81. PMID: 16964262

6. Peng, J. et al. (2010) European journal of immunology 40, 1738-47. PMID: 20306472

7. Murata, H. et al. (2018) The Journal of biological chemistry 293, 18933-18943. PMID: 30333228

Nota

For research use only

Imágenes

Referencias

Datasheet

Anti-Human SARM1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

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