Anti-Human SARM1 Polyclonal Antibody (HD538014)

Name: Anti-Human SARM1 Polyclonal Antibody
Brand: abinScience
SKU: HD538014
Price: 168 USD
Availability: InStock

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Fiche technique
SDS

Aperçu

Numéro de catalogue

HD538014

Description

Anti-Human SARM1 Polyclonal Antibody (HD538014) is a rabbit polyclonal antibody detecting SARM1. Suitable for Human, Rat, and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human SARM1 (Gly56-Gly398).

Cible

EC:3.2.2.-, EC:3.2.2.6, HsTIR, KIAA0524, MyD88-5, NAD(+) hydrolase SARM1, NADP(+) hydrolase SARM1, NADase SARM1, SAM domain-containing protein 2, SAMD2, SARM, SARM1, Sterile alpha and Armadillo repeat protein, Sterile alpha and TIR motif-containing protein 1, Sterile alpha motif domain-containing protein 2, Tir-1 homolog, hSARM1

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

Q6SZW1

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Contexte

NAD(+) hydrolase SARM1 is a ~79 kDa protein. NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules. Can activate neuronal cell death in response to stress.

1. Gerdts, J. et al. (2015) Science (New York, N.Y.) 348, 453-7. PMID: 25908823

2. Summers, DW. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, E6271-E6280. PMID: 27671644

3. Essuman, K. et al. (2017) Neuron 93, 1334-1343.e5. PMID: 28334607

4. Liberati, NT. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 6593-8. PMID: 15123841

5. Carty, M. et al. (2006) Nature immunology 7, 1074-81. PMID: 16964262

6. Peng, J. et al. (2010) European journal of immunology 40, 1738-47. PMID: 20306472

7. Murata, H. et al. (2018) The Journal of biological chemistry 293, 18933-18943. PMID: 30333228

Note

For research use only

Images

Reférences

Fiche technique

Anti-Human SARM1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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