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| カタログ番号 | HD538014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SARM1 Polyclonal Antibody (HD538014) is a rabbit polyclonal antibody detecting SARM1. Suitable for Human, Rat, and Mouse.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SARM1 (Gly56-Gly398). | ||||||||
| ターゲット | EC:3.2.2.-, EC:3.2.2.6, HsTIR, KIAA0524, MyD88-5, NAD(+) hydrolase SARM1, NADP(+) hydrolase SARM1, NADase SARM1, SAM domain-containing protein 2, SAMD2, SARM, SARM1, Sterile alpha and Armadillo repeat protein, Sterile alpha and TIR motif-containing protein 1, Sterile alpha motif domain-containing protein 2, Tir-1 homolog, hSARM1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q6SZW1 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | NAD(+) hydrolase SARM1 is a ~79 kDa protein. NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules. Can activate neuronal cell death in response to stress. 1. Gerdts, J. et al. (2015) Science (New York, N.Y.) 348, 453-7. PMID: 25908823 2. Summers, DW. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, E6271-E6280. PMID: 27671644 3. Essuman, K. et al. (2017) Neuron 93, 1334-1343.e5. PMID: 28334607 4. Liberati, NT. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 6593-8. PMID: 15123841 5. Carty, M. et al. (2006) Nature immunology 7, 1074-81. PMID: 16964262 6. Peng, J. et al. (2010) European journal of immunology 40, 1738-47. PMID: 20306472 7. Murata, H. et al. (2018) The Journal of biological chemistry 293, 18933-18943. PMID: 30333228 | ||||||||
| 注意事項 | For research use only |
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